Aquilos 2 Cryo-FIB
Dedicated cryo-FIB microscope to prepare cryo-lamellas for cryo-electron tomography
The Thermo Scientific Aquilos 2 Cryo-FIB is dedicated to the preparation of thin, electron-transparent lamellas for high-resolution cellular cryo-electron tomography or MicroED of micro-crystals. With the Aquilos 2 Cryo-FIB, you can automate steps in the workflow to produce multiple lamellas from specific programmed locations. The improved dedicated cryo-hardware provides longer run times at ultra-low contamination rates.
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Features
Correlative fluorescence and electron imaging in one system
The iFLM Correlative System (Integrative Fluorescence Light Microscope) allows you to combine fluorescence imaging and ion milling within a single cryo-FIB SEM microscope.
3D visualization
With Thermo Scientific Auto Slice and View Software, you can acquire 3D images from vitrified samples by sequential milling and then imaging of the cross-section of a defined volume of the sample. This process will help you stop milling at the correct subcellular region to prepare your lamella before you observe the ultrastructural detail in your cryo-TEM using cryo-ET.
Automated batch cryo-lamella milling
Explore state-of-the-art automation for cryo-lamella production and work with challenging bulk-frozen samples that require cryo-lift-out sample preparation.
Cryo-lift-out lamella preparation
Prepare lamellas from specific targeted regions with nanometer-position accuracy. The high-precision EasyLift NanoManipulator option allows for extraction of site-specific regions, such as fluorescently labeled proteins, even from high-pressure frozen samples. These lamellas can subsequently be placed inside Autogrids for cryo-TEM and further imaging of protein structures and protein networks.
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